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fluvoxamine will raise the degree or effect of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.bosentan will reduce the extent or impact of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.Manufacturers state that diazepam is contraindicated in patients with acute